Issue 10 NEWSLETTER January 2000
CRASH right on target!
The graph below shows the recruitment in the CRASH trial compared to that in the International Stroke Trial (IST) which went on to recruit 19,436 patients.
The CRASH trial is rapidly becoming one of the largest trials of corticosteroids in head injury with close to 300 patients now randomised.
International news…

In Namur, Belgium - Guy Mazairac got off to a speedy start with recruitment. After getting his first box of treatment packs on Christmas eve, he randomised the first Belgian patient on the 30th December. He is now well into his second box and is also encouraging his emergency care colleagues to get involved in the trial as well. 

Sri Lanka also got off to a tremendous start in the New Year with Véronique Laloe randomising the first patient in to the trial on the 2nd January 2000. A second hospital in Sri Lanka – the National Hospital in Colombo will be starting recruitment soon. Thanks to Sunil Perera, consultant neurosurgeon at the National Hospital in Colombo for getting the trial ready to go. 

Trial recruitment is going very well in Durban, South Africa. Many thanks to Naren Nathoo, consultant neurosurgeon at Wentworth Hospital for his work. 

And, congratulations to Patrick Plunkett and Geraldine MacMahon at St. James Hospital in Dublin, Ireland - the most recent international centre to start randomisation!

And in the UK …

Randomisation of patients in the UK hit a high over the holiday period with three times as many patients being randomised during this period compared with other times of the year. 

Fax randomisation during the telephone randomisation ‘millennium shut-down’ worked smoothly – and the FREEPHONE randomisation service is now up and running without any glitches thanks to Hugh Bettesworth, the programmer for the CRASH trial at CTSU.

New centres that have started to recruit patients recently include Alison Pickford & Julie Nancarrow at Blackburn Royal Infirmary; Ian Stell & Maureen Clarke at Bromley Hospital; Lawrence Jaffey & Michael Graves at the Royal Liverpool University Hospital. All three centres have now randomised their first patient. The most recent centre to start recruitment is the Queen Elizabeth Hospital in Birmingham - Sister Debbie Ford and consultant neurosurgeon Jonathan Wasserberg taking the lead at QEH. 

Thanks to Sister Gabby Lomas and all the enthusiastic nurses and doctors at Hope Hospital – the top UK recruiting centre with 43 randomised patients.

Pramod Luthra at the Royal Oldham Hospital is the newest centre to receive CRASH trial treatment packs – we look forward to recruitment starting soon.

There will be a presentation on the CRASH trial at the Intensive Care and Emergency Medicine meeting in Brussels, 21-24 March 2000. Petr Svoboda the Czech Republic National Co-ordinator will also be attending the meeting. We are planning to hold an informal meeting for any new collaborators from Belgium (or from other countries) at the meeting. Please contact me if you would like to find out more about the conference or the CRASH trial meeting.
CRASH Trial Co-ordinator, Nin Ritchie

CRASH Co-ordinating Centre, FREEPOST LON 14211, LONDON WC1N 1BR

Tel: + 44 (0)20 7299 4684 Fax: + 44 (0)20 7299 4663 email:

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