Issue 16 N E W S L E T T E R July 2000
Just over a year into the trial and we have every reason to feel proud.  We have 39 hospitals in seven countries actively recruiting and by the end of the year CRASH will be the largest randomised trial in head injury ever conducted.  But to reach the target of 20,000 patients we need sustained serious recruitment at a large number of hospitals.

The table below shows monthly average recruitment for the randomising hospitals.  The average ranges from nine patients per month to less than one.  Some, but certainly not all, of this difference is explained by differences in head injury attendance.  It is more likely that the big recruiters are hospitals where as many eligible patients as possible are considered for trial entry.  To achieve this, considering patients for the trial must be part of the standard clinical care of patients with head injury.  This means that every nurse and doctor caring for patients with head injuries must know about the trial and how to enter patients.

CRASH must be the collective passion of a centre and not just the private passion of an individual.  As the table shows, serious recruitment can be achieved in many different countries, but this requires a sustained collaborative effort.  The CRASH trial belongs to the collaborators and it is up to us to make it a success.  Keep randomising and keep evangelising!                   Ian Roberts Clinical Co-ordinator

Hospital          Patients
Centre Hospitalier Regional de Namur Belgium                 8.8
Research Institute for Special Surgery and Trauma Czech Republic                 8.5
Trauma Centre - Virgen Del Rocio Spain                 5.9
Hope Hospital Salford, Manchester, UK                 4.6
Wentworth Hospital South Africa                 3.7
North Manchester General Hospital Crumpsall, Manchester, UK                 3.4
Selly Oak Hospital Selly Oak, Birmingham, UK                 3.3
University Hospital of Zurich Switzerland                 2.4
National Hospital of Sri Lanka Sri Lanka                 2.3
St James's University Hospital Eire                 2.0
Northern General Hospital Sheffield, S Yorkshire, UK                 2.0
Birmingham Heartlands Hospital Birmingham, West Midlands, UK                 1.8
Whiston Hospital Prescot, Merseyside, UK                 1.5
Royal Bolton Hospital Bolton, Lancs, UK                 1.5
Stepping Hill Hospital Stockport, Cheshire, UK                 1.3
Royal Albert Edward Infirmary Wigan, Lancs, UK                 1.3
Batticaloa General Hospital, Teaching Sri Lanka                 1.3
Masaryk Hospital Czech Republic                 1.3
Princess Alexandra Hospital Harlow, Essex, UK                 1.2
Reimann Hospital Slovakia                 1.2
Colchester General Hospital Colchester, Essex, UK                 1.1
Trafford General Hospital Davyhulme, Manchester, UK                 1.0
Countess of Chester Hospital Chester, Cheshire, UK                 1.0
Queen Elizabeth Hospital, Birmingham Edgbaston, Birmingham, UK                 1.0
Royal Oldham Hospital Oldham, Lancs, UK                 0.9
Eastbourne District General Hospital Eastbourne, E Sussex, UK                 0.9
Bury General Hospital Bury, Lancs, UK                 0.9
Blackburn Royal Infirmary Blackburn, Lancs, UK                 0.8
Furness General Hospital Barrow-in-Furness, Cumbria, UK                 0.8
Cheltenham General Hospital Cheltenham, Glos, UK                 0.7
A.Z. Kliena Hospital Belgium                 0.6
Aberdeen Royal Infirmary Aberdeen, Grampian, UK                 0.6
Hospital Pribram Czech Republic                 0.5
Queen Elizabeth The Queen Mother Hospital Kent, UK                 0.5
Royal Liverpool University Hospital Liverpool, Merseyside, UK                 0.4
Doncaster Royal Infirmary Doncaster, S Yorkshire, UK                 0.2
Bromley Hospital Bromley, Kent, UK                 0.1
Harrogate District Hospital Harrogate, N Yorkshire, UK                 0.1

  • Jean Ciurea in Dr D Bagdasar Clinical Hospital in Romania has received an Ethics Committee approval.  The first box of treatment packs should be on its way shortly.
  • Roberto Lede of IAMBE in Argentina is  taking on the role of regional co-ordinator in South and Central America.  Oscar Palma in Costa Rica has applied for ethics approval and is awaiting the  outcome.
  • Recruiter of the month is Guy Mazairac in Centre Hospitalier Regional de  Namur. 
  • Andrea Sauerland is leaving University Hospital of Zurich; thanks to Andrea for all the work she has done setting up CRASH in Switzerland.  Silke Ludwig is taking on the role as collaborator - welcome to Silke!

CRASH Trial Co-ordinator, Nin Ritchie

CRASH Co-ordinating Centre, FREEPOST LON 14211, LONDON WC1N 1BR

Tel: + 44 (0)20 7299 4684 Fax: + 44 (0)20 7299 4663 email:

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